1-Bromo-2-chloro-4,5-dimethoxybenzene
نویسندگان
چکیده
The mol-ecule of the title compound, C(8)H(8)BrClO(2), sits on a crystallographic inversion centre, which ensures that the halogen sites are disordered, with exactly 50% Br and 50% Cl at each halogen site. The inversion renders the two meth-oxy groups equivalent. These groups lie almost in the plane of the aromatic ring system, making dihedral angles of 8.8 (4)° to the ring.
منابع مشابه
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Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.
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Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted withsecondary amines in boiling ethanol to afford the related 7-amino derivatives.
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The halogen atoms of the title compound, C(8)H(6)BrCl(3)O(2), are located within the plane of the benzene ring [r.m.s. deviation = 0.036 (11) Å]. The two meth-oxy groups are twisted out of this plane, with dihedral angles of 84.7 (3) and 68.5 (3)°, and point in opposite directions. The structure is disordered by a non-crystallographic twofold rotation which superimposes Cl and Br at two of the ...
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